Exploring the Impact of Performance-Based Funding Policy Reform: The Role of Institutional Research in Supporting Data-Driven Decision-Making

The institutional pressures placed on the Ontario college system, exercised through funding model reform, brought forward organizational challenges difficult for even the most fiscally savvy to navigate. The enrollment corridor mechanism and the expansion of the proportions of the differentiation envelope to create a performance-based grant, implemented via the 2020-25 Strategic Mandate Agreement (SMA3), demonstrate the Provincial Government’s calls for efficiencies and accountability and the alignment of institutional and provincial priorities. Remaining financially sustainable while moving from performance reporting to performance funding and weathering the impacts of the Covid-19 pandemic requires a solid understanding of not only enrollment challenges and opportunities but also data and information used to inform decisions. Institutional Research (IR) units are responsible for providing leaders with data and information for this work. However, access to data and information does not imply their effective use (Marsh et al., 2006), pointing to a gap in data literacy skills amongst higher education leaders (Mathies, 2018). The problem of practice that will be examined is the role of IR in supporting effective data-driven decision-making related to achievement of the College X enrollment and SMA3 priorities. This Organizational Improvement Plan proposes that an existing Strategic Enrollment Management governance structure be leveraged for development and implementation of a group-level capacity building strategy. The planned change is used to inform enhancements to existing data tools and resources responsive to stakeholder needs and mindful of organizational context. The Change Path Model (Cawsey et al., 2016) provides the framework to implement this solution using distributed and adaptive leadership approaches

How compliant are technicians with universal safety measures in medical laboratories in Croatia?

Introduction: This pilot study aimed to investigate the use of personal protective equipment (PPE) and compliance to the code of conduct (rules defined in institutional, governmental and professional guidelines) among laboratory technicians in Croatian medical laboratories. In addition, we explored the differences in compliance between participants of different age groups, laboratory ownership and accreditation status. Materials and methods: An anonymous and voluntary survey with 15 questions was conducted among Croatian medical laboratory technicians (N = 217). The questions were divided into two groups: demographic characteristics and the use of PPE. The questions of the second part were graded according to the Likert scale (1-4) and an overall score, shown as median and range (min-max), was calculated for each participant. Differences between the overall scores were tested for each group of participants. Results: The majority of participants always wear protective clothes at work, 38.7% of them always wear gloves in daily routine, more than 30.0% consume food and almost half of them drink beverages at workplace. A significantly lower overall score was found for participants working in public compared to private laboratories (36 (16-40) vs. 40 (31-40), P < 0.001). There were no statistically significant differences in overall scores for participants of different age groups (P = 0.456) and laboratory accreditation status (P = 0.081). Conclusion: A considerable percentage of laboratory technicians in Croatian medical laboratories do not comply with safety measures. Lack of compliance is observed in all personnel regardless laboratory accreditation and participants’ age. However, those working in private laboratories adhere more to the code of conduct

Design, Synthesis and Pharmacological Evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)-ethyl]-phenyl}-arylamides

5HT1A receptor targeting drugs have been used as the treatment for the many neuropsychiatric disorders, such as schizophrenia and depression. As a part of ongoing research, we designed series of new compounds that share arylpiperazine common structural motif with the 5HT1A receptor ligand aripiprazole. Receptor-ligand interactions were determined by the molecular docking simulations, revealing the positive impact of the phenyl substitution in the arylpiperazine part of the molecules. Nine selected compounds were synthesized in four reaction steps in high overall yields (59-73%). In vitro pharmacological evaluation of the synthesized compounds revealed three compounds (5b, 6b and 6c) with high 5HT1A binding affinity, comparable with aripiprazole (Ki 12.0, 4.8, 12.8, 5.6 nM, respectively). Compounds from b series, 5b and 6b, possess 2-methoxyphenyl substituents, while 6c possess 2,3-dichlorophenyl substituent in the arylpiperazine part of the molecule. The pharmacological results are therefore in accordance with the molecular docking simulations thus proving the rational design. Compounds 5c, 6b and 6c can be considered as the candidates for further evaluation as new, potential antidepressants

Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency

Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment

An introduction to Serbian piano music: Musical and cultural influences on three selected composers

Serbia is a country that has survived many political and religious conflicts. Perhaps the best way to describe Serbian culture and tradition would be a country whose inhabitants struggled for many years, yet managed to incorporate the best elements of its conquerors’ cultures. Serbian musical identity is an amalgam of local and international influences and styles. Different foreign authorities occupied this country for centuries. The Danube River was the main border of the Austro-Hungarian Empire, located in the north, and the Turkish Ottoman Empire, situated south of the Danube. The Austro-Hungarian influences on Serbian music are most evident in piano music played at numerous salons, while the Ottoman Empire’s impact derives from its folk melodies and rhythms that were absorbed into Serbian culture. This document focuses on three Serbian composers from three different eras, educated in three distinct cultures. The first composer, Kornelije Stankovic was the first Serbian composer to be educated in Vienna; his studies were shaped by the salon music of the Austro-Hungarian Empire and by traditional Serbian folk music. The second composer, Isidor Bajic was educated in Budapest; his piano works, popular among young musicians are included here due to their impact on the development of classical music in Serbia. Svetozar Sasa Kovacevic, the third Serbian composer, was trained entirely in Serbia and wrote music inspired by Bach and Liszt. This presentation and description of selected Serbian music will benefit pianists of any nationality. Those of Serbian heritage will recognize the development of their nation’s musical style throughout history, as exemplified by the chosen composers’ musical input; and non Serbian performers will have the opportunity to develop an appreciation for the great piano works composed in Serbia. The multinational threads of Serbian music history present a beautiful image: a country, resolutely persisting despite oppression, gathering worthy musical elements to create a unique tapestry

An introduction to Serbian piano music: Musical and cultural influences on three selected composers

Serbia is a country that has survived many political and religious conflicts. Perhaps the best way to describe Serbian culture and tradition would be a country whose inhabitants struggled for many years, yet managed to incorporate the best elements of its conquerors’ cultures. Serbian musical identity is an amalgam of local and international influences and styles. Different foreign authorities occupied this country for centuries. The Danube River was the main border of the Austro-Hungarian Empire, located in the north, and the Turkish Ottoman Empire, situated south of the Danube. The Austro-Hungarian influences on Serbian music are most evident in piano music played at numerous salons, while the Ottoman Empire’s impact derives from its folk melodies and rhythms that were absorbed into Serbian culture. This document focuses on three Serbian composers from three different eras, educated in three distinct cultures. The first composer, Kornelije Stankovic was the first Serbian composer to be educated in Vienna; his studies were shaped by the salon music of the Austro-Hungarian Empire and by traditional Serbian folk music. The second composer, Isidor Bajic was educated in Budapest; his piano works, popular among young musicians are included here due to their impact on the development of classical music in Serbia. Svetozar Sasa Kovacevic, the third Serbian composer, was trained entirely in Serbia and wrote music inspired by Bach and Liszt. This presentation and description of selected Serbian music will benefit pianists of any nationality. Those of Serbian heritage will recognize the development of their nation’s musical style throughout history, as exemplified by the chosen composers’ musical input; and non Serbian performers will have the opportunity to develop an appreciation for the great piano works composed in Serbia. The multinational threads of Serbian music history present a beautiful image: a country, resolutely persisting despite oppression, gathering worthy musical elements to create a unique tapestry

Longitudinal Course of Sex Steroids From Pregnancy to Postpartum

CONTEXT: Sex steroids (SS) typically rise during pregnancy and decline after birth, but no consistent reference values exist for these hormonal courses. We aimed to establish an overview of SS secretion patterns during the peripartum and to better understand how SS contribute to maternal and fetal pathologies. EVIDENCE ACQUISITION: A systematic literature search was conducted in accordance with the PRISMA guidelines using PubMed, Cochrane Library, and PsycINFO. Additionally, we conducted a supplementary manual search of references. Observational studies published in English and assessing estradiol, progesterone, and testosterone over the course of the peripartum in physically healthy female subjects were included, without restrictions on year of publication. Extracted data were analyzed descriptively and visually. EVIDENCE SYNTHESIS: SS increase progressively during pregnancy, with an extremely wide range of reported concentrations, especially in the third trimester. In fact, reported concentrations varied up to 5000-fold at comparable measurement time points. CONCLUSIONS: A comprehensive understanding of the influence of SS levels on associated maternal and fetal pathologies is currently hindered by 2 main factors. First, reported SS levels vary widely during the peripartum period. Second, the current state of knowledge on how SS are associated with pathologies in mothers and babies is largely based on correlational studies, and causality thus remains unclear. Consequently, we recommend the development of a systematic reference framework that follows the suggestions presented in this review. This would enable the establishment of SS reference values for a healthy population, resulting in the possibility to draw conclusions about deviations and related pathologies

Trajectories of reproductive transition phase mood disorder from pregnancy to postpartum: A Swiss longitudinal study

Background: Depressive symptoms are common in the peripartum period and pose a great risk to the well-being of the mother, the infant, and the entire family. Evidence from longitudinal studies suggests that affected women do not constitute one homogeneous group in terms of severity, chronicity, and onset of symptoms. To account for individual differences regarding the longitudinal course of depressive symptoms from pregnancy to the postpartum period, growth mixture models have proven to be useful. Methods: We conducted a group-based trajectory modeling analysis to identify perinatal depressive symptom trajectories in a Swiss sample ( n = 151). Depressive symptoms were assessed six times, covering nearly 6 months from the third trimester of pregnancy to 3 months postpartum. In addition to determining perinatal depressive symptom trajectories, we aimed to examine whether these trajectories are linked to psychopathological risk factors such as a history of premenstrual syndrome (PMS), anxiety, prenatal stress, and somatic symptoms after delivery that are associated with hormonal fluctuations. Results: The findings revealed three trajectories of perinatal depressive symptoms that were relatively stable over time and differed in symptom load (low, medium, high), as well as one trajectory of decreasing symptoms, with a significant symptom reduction after giving birth. Women with a higher depressive symptom load experienced a greater degree of prior premenstrual symptoms, prenatal anxiety, and birth anxiety, as well as somatic symptoms after delivery. Conclusion: Further research is needed to account for the distinct trajectories of perinatal depressive symptoms in order to provide appropriate care for affected women. A focus on somatic symptoms after delivery and their association with depressive mood is essential to better understand the potential shared etiopathology of reproductive transition phase mood disorders

Phenolic Compounds in Field Horsetail (Equisetum arvense L.) as Natural Antioxidants

In this paper, the study of antioxidant activity and phenolic composition of three different extracts (EtOAc, n-BuOH and H2O) of field horsetail (Equisetum arvense L.) is presented. The antioxidant activity has been evaluated measuring the total reducing power (expressed by Ascorbate Equivalent Antioxidant Capacity - AEAC), inhibition of lipid peroxidation, and free radical scavenging capacity (RSC) towards 2,2-diphenyl-1- picrylhydrazyl (DPPH radical) and nitric oxide (NO), respectively. In addition, the total flavonoid content (TFC) and phenolic constituents of each extract have been determined. The results obtained show that the highest RSC regarding both DPPH and NO radicals is expressed by EtOAc extract (EC50=2.37 μg/mL and EC50=90.07 μg/mL, respectively), and the lowest by H2O extract (EC50=37.2 μg/mL and EC50>333.33 μg/mL, respectively). n- BuOH extract showed the highest total reducing power (AEAC=13.40 μg/mL). Differences in the phenolic composition of examined extracts are found comparing the HPLC chemical profiles. Although, isoquercitrin is the main flavonoid in both EtOAc and n-BuOH extracts, a considerable amount of di-E-caffeoyl-meso-tartaric acid was presented in the n-BuOH extract. In H2O extract high content of phenolic acids and low percentage of flavonoids were detected